Darrell Wilcox, MD 10/23/26 Darrell Wilcox, MD 10/23/26

Testosterone for Women: Not Just Libido. Bone, Brain, Muscle After 40

Testosterone in women is not only a libido story. Androgen receptors sit in bone, muscle, and brain. The strongest randomized evidence is still sexual function. Bone, lean mass, and cognition remain incompletely tested.

Darrell Wilcox, MD 9/21/26 Darrell Wilcox, MD 9/21/26

Your Labs Might Be Showing a Sleep Problem, Not a Testosterone Problem

Most of your daily testosterone release happens during sleep. A single rough week can drop a lab result before anything's actually wrong.

Darrell Wilcox, MD 9/18/26 Darrell Wilcox, MD 9/18/26

Should You Block Estrogen on TRT? What the Research Shows

Crashing your estradiol on TRT isn't optimization. The landmark trial that separated testosterone's effects from estrogen's found low estradiol drives fat gain, bone loss, and sexual dysfunction.

Darrell Wilcox, MD 9/7/26 Darrell Wilcox, MD 9/7/26

Your Hair Is Thinning on Hormone Therapy. Testosterone Isn't Always the Reason.

More hair in the shower drain after starting hormone therapy? The dose isn't always the culprit. Here's what's actually driving it, and how to find out.

Darrell Wilcox, MD 9/4/26 Darrell Wilcox, MD 9/4/26

Your Testosterone Isn't Just Declining With Age. It's Declining Across Generations.

In 2017, LabCorp lowered its normal testosterone range for men. That change didn't happen in a vacuum, it responded to a decline researchers had already been tracking for years.

Darrell Wilcox, MD 8/14/26 Darrell Wilcox, MD 8/14/26

GLP-1 and Hormone Optimization Aren't Competing Treatments. Here's Why They're Better Together

GLP-1 medications control appetite. They don't control the hormones that determine your muscle, metabolism, or where you store fat. Here's why combining both gets better results than either alone.

Darrell Wilcox, MD 7/7/26 Darrell Wilcox, MD 7/7/26

Injections, Creams, Pellets, Pills, Troches: Which Hormone Delivery Method Is Actually Right for You?

Injections, creams, pellets, pills, troches. The delivery method changes how a hormone actually behaves in your body, not just how you take it. Here's the mechanism behind each route, and how to think about which one fits you.

Darrell Wilcox, MD 6/30/26 Darrell Wilcox, MD 6/30/26

You're Not Losing Muscle Because You Got Lazy

You still train just as hard. So why is the result half what it used to be? The honest answer usually isn't effort. It's a muscle-building signal that quietly fades with age, and a standard lab panel that never measures the part that matters.

Darrell Wilcox, MD 6/23/26 Darrell Wilcox, MD 6/23/26

Progesterone Is Being Prescribed to Men. Here's Why That's a Problem.

The same compound class used clinically to suppress male sexual function is being prescribed by some providers for hormone "balance." Here's what the data actually shows.

Darrell Wilcox, MD 6/9/26 Darrell Wilcox, MD 6/9/26

Anastrozole in Men on TRT: What It Does, When It Helps, and When It Doesn’t

Many men on testosterone therapy are prescribed anastrozole as a matter of routine. But blanket estrogen suppression often creates the very problems it’s meant to fix—including, paradoxically, the gynecomastia it was supposed to prevent.

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