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Physician-written perspectives on the latest research and the questions patients ask most. Start with the newest article below, or explore a topic.
If You're on Testosterone and an Estrogen Blocker: Drive Gone, Midsection Growing
On testosterone plus an estrogen blocker with drive gone and midsection growing? Part of testosterone's message is estradiol. NEJM work linked estrogen deficiency to more body fat and showed both hormones regulate sexual function. Confirm sensitive estradiol plus SHBG and a real clinical reason before a blocker.
Your Labs Might Be Showing a Sleep Problem, Not a Testosterone Problem
Most of your daily testosterone release happens during sleep. A single rough week can drop a lab result before anything's actually wrong.
Should You Block Estrogen on TRT? What the Research Shows
Crashing your estradiol on TRT isn't optimization. The landmark trial that separated testosterone's effects from estrogen's found low estradiol drives fat gain, bone loss, and sexual dysfunction.
Your Testosterone Isn't Just Declining With Age. It's Declining Across Generations.
In 2017, LabCorp lowered its normal testosterone range for men. That change didn't happen in a vacuum, it responded to a decline researchers had already been tracking for years.
You're Not Losing Muscle Because You Got Lazy
You still train just as hard. So why is the result half what it used to be? The honest answer usually isn't effort. It's a muscle-building signal that quietly fades with age, and a standard lab panel that never measures the part that matters.
Progesterone Is Being Prescribed to Men. Here's Why That's a Problem.
The same compound class used clinically to suppress male sexual function is being prescribed by some providers for hormone "balance." Here's what the data actually shows.
Anastrozole in Men on TRT: What It Does, When It Helps, and When It Doesn’t
Many men on testosterone therapy are prescribed anastrozole as a matter of routine. But blanket estrogen suppression often creates the very problems it’s meant to fix—including, paradoxically, the gynecomastia it was supposed to prevent.