Crashing your estradiol on TRT isn't optimization. The landmark trial that separated testosterone's effects from estrogen's found low estradiol drives fat gain, bone loss, and sexual dysfunction.

A meningioma headline about progesterone is usually actually about one specific synthetic progestin. Here's what the research shows about which ones carry real risk, and which don't.

Estrogen and blood clot warnings usually skip two details that actually determine the risk: timing after menopause and route of administration. Here's what the randomized trials actually show.