Darrell Wilcox, MD 10/23/26 Darrell Wilcox, MD 10/23/26

Testosterone for Women: Not Just Libido. Bone, Brain, Muscle After 40

Testosterone in women is not only a libido story. Androgen receptors sit in bone, muscle, and brain. The strongest randomized evidence is still sexual function. Bone, lean mass, and cognition remain incompletely tested.

Darrell Wilcox, MD 10/16/26 Darrell Wilcox, MD 10/16/26

Oral vs Transdermal Estrogen and IGF-1: Why Route Determines Peptide Response

Oral estrogen and transdermal estradiol are not the same for IGF-1. First-pass through the liver helps explain why IGF-1 can stall on oral estrogen even when GH or a GH-axis peptide looks active upstream. Route is part of the foundation.

Darrell Wilcox, MD 10/5/26 Darrell Wilcox, MD 10/5/26

Why You're Wide Awake at 2 AM (And It's Not Stress)

If you're suddenly wide awake at 2 AM and it started sometime in your 40s, it's probably not stress. It's a specific, measurable hormone mechanism.

Darrell Wilcox, MD 9/25/26 Darrell Wilcox, MD 9/25/26

Does Progesterone Cause Bloating? What the Research Actually Shows

Progesterone gets blamed for bloating and breast tenderness on hormone therapy, but it actually blocks the receptor that causes fluid retention. Here's what's really going on.

Darrell Wilcox, MD 9/11/26 Darrell Wilcox, MD 9/11/26

Does Progesterone Cause Brain Tumors? What the Research Actually Shows

A meningioma headline about progesterone is usually actually about one specific synthetic progestin. Here's what the research shows about which ones carry real risk, and which don't.

Darrell Wilcox, MD 9/7/26 Darrell Wilcox, MD 9/7/26

Your Hair Is Thinning on Hormone Therapy. Testosterone Isn't Always the Reason.

More hair in the shower drain after starting hormone therapy? The dose isn't always the culprit. Here's what's actually driving it, and how to find out.

Darrell Wilcox, MD 8/31/26 Darrell Wilcox, MD 8/31/26

Does Estrogen Cause Blood Clots and Strokes? What the Actual Trial Data Shows

Estrogen and blood clot warnings usually skip two details that actually determine the risk: timing after menopause and route of administration. Here's what the randomized trials actually show.

Darrell Wilcox, MD 8/10/26 Darrell Wilcox, MD 8/10/26

Oral Estradiol and Breast Cancer Risk: What the Evidence Actually Says

Two physicians told her oral estrogen was too risky and offered nothing in its place. Neither had looked closely at which estrogen the research actually studied. Here's what the evidence shows, and why the fear doesn't hold up.

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