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Physician-written perspectives on the latest research and the questions patients ask most. Start with the newest article below, or explore a topic.

Darrell Wilcox, MD 10/9/26 Darrell Wilcox, MD 10/9/26

The Control Room for Your Sleep: Two Signals, Fighting All Day, Deciding When You Crash

There are two competing signals deciding when you get sleepy, not one. Understanding them explains second winds, jet lag, and why you can be exhausted but wide awake.

Darrell Wilcox, MD 8/28/26 Darrell Wilcox, MD 8/28/26

Adrenal Fatigue Isn't a Diagnosis. Cellular Cortisol Resistance Is.

Adrenal fatigue is not a standard medical diagnosis. Symptoms can be real even when that label is wrong. Chronic stress can mute how cells hear cortisol while blood levels still look fine.

Darrell Wilcox, MD 8/24/26 Darrell Wilcox, MD 8/24/26

Your Thyroid Isn't Broken. The Enzyme That Activates It Might Be.

Your thyroid gland might be working fine. The enzyme that activates thyroid hormone at the cellular level is a different story. Here's the mechanism.

Darrell Wilcox, MD 4/18/26 Darrell Wilcox, MD 4/18/26

Why Your Labs Look Normal But You Feel Terrible

Your doctor says your labs are fine. So why do you still feel exhausted, foggy, and off? The problem isn't your results — it's what "normal" actually means, and what most standard panels never measure.