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Physician-written perspectives on the latest research and the questions patients ask most. Start with the newest article below, or explore a topic.
Should You Block Estrogen on TRT? What the Research Shows
Crashing your estradiol on TRT isn't optimization. The landmark trial that separated testosterone's effects from estrogen's found low estradiol drives fat gain, bone loss, and sexual dysfunction.
Does Progesterone Cause Brain Tumors? What the Research Actually Shows
A meningioma headline about progesterone is usually actually about one specific synthetic progestin. Here's what the research shows about which ones carry real risk, and which don't.
Does Estrogen Cause Blood Clots and Strokes? What the Actual Trial Data Shows
Estrogen and blood clot warnings usually skip two details that actually determine the risk: timing after menopause and route of administration. Here's what the randomized trials actually show.
Oral Estradiol and Breast Cancer Risk: What the Evidence Actually Says
Two physicians told her oral estrogen was too risky and offered nothing in its place. Neither had looked closely at which estrogen the research actually studied. Here's what the evidence shows, and why the fear doesn't hold up.
Progesterone Is Being Prescribed to Men. Here's Why That's a Problem.
The same compound class used clinically to suppress male sexual function is being prescribed by some providers for hormone "balance." Here's what the data actually shows.
Anastrozole in Men on TRT: What It Does, When It Helps, and When It Doesn’t
Many men on testosterone therapy are prescribed anastrozole as a matter of routine. But blanket estrogen suppression often creates the very problems it’s meant to fix—including, paradoxically, the gynecomastia it was supposed to prevent.