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Physician-written perspectives on the latest research and the questions patients ask most. Start with the newest article below, or explore a topic.

Darrell Wilcox, MD 10/23/26 Darrell Wilcox, MD 10/23/26

Testosterone for Women: Not Just Libido. Bone, Brain, Muscle After 40

Testosterone in women is not only a libido story. Androgen receptors sit in bone, muscle, and brain. The strongest randomized evidence is still sexual function. Bone, lean mass, and cognition remain incompletely tested.

Darrell Wilcox, MD 10/5/26 Darrell Wilcox, MD 10/5/26

Why You're Wide Awake at 2 AM (And It's Not Stress)

If you're suddenly wide awake at 2 AM and it started sometime in your 40s, it's probably not stress. It's a specific, measurable hormone mechanism.

Darrell Wilcox, MD 8/31/26 Darrell Wilcox, MD 8/31/26

Does Estrogen Cause Blood Clots and Strokes? What the Actual Trial Data Shows

Estrogen and blood clot warnings usually skip two details that actually determine the risk: timing after menopause and route of administration. Here's what the randomized trials actually show.

Darrell Wilcox, MD 8/10/26 Darrell Wilcox, MD 8/10/26

Oral Estradiol and Breast Cancer Risk: What the Evidence Actually Says

Two physicians told her oral estrogen was too risky and offered nothing in its place. Neither had looked closely at which estrogen the research actually studied. Here's what the evidence shows, and why the fear doesn't hold up.

Darrell Wilcox, MD 5/2/26 Darrell Wilcox, MD 5/2/26

What Is Bioidentical Hormone Replacement Therapy — and Is It Right for You?

The term "bioidentical" gets used loosely — but the distinction from synthetic hormones is real and clinically significant. Here's what BHRT actually is, which hormones are involved, and how to think about whether it belongs in your care.