Darrell Wilcox, MD 9/28/26 Darrell Wilcox, MD 9/28/26

Your Glucose Is Normal. Your Insulin Already Isn't.

Insulin rises years before glucose ever moves. Low SHBG, a high triglyceride-to-HDL ratio, and acanthosis nigricans are all reasons to check fasting insulin directly.

Darrell Wilcox, MD 9/25/26 Darrell Wilcox, MD 9/25/26

Does Progesterone Cause Bloating? What the Research Actually Shows

Progesterone gets blamed for bloating and breast tenderness on hormone therapy, but it actually blocks the receptor that causes fluid retention. Here's what's really going on.

Darrell Wilcox, MD 9/21/26 Darrell Wilcox, MD 9/21/26

Your Labs Might Be Showing a Sleep Problem, Not a Testosterone Problem

Most of your daily testosterone release happens during sleep. A single rough week can drop a lab result before anything's actually wrong.

Darrell Wilcox, MD 9/18/26 Darrell Wilcox, MD 9/18/26

Should You Block Estrogen on TRT? What the Research Shows

Crashing your estradiol on TRT isn't optimization. The landmark trial that separated testosterone's effects from estrogen's found low estradiol drives fat gain, bone loss, and sexual dysfunction.

Darrell Wilcox, MD 9/14/26 Darrell Wilcox, MD 9/14/26

Your Thymus Didn't Disappear After Puberty. It Just Went Quiet.

Your thymus doesn't fully shut off after puberty, it just slows down, and it's still measurably active decades later. Here's what that means for your immune resilience, and where research on thymosin alpha-1 shows the most promise.

Darrell Wilcox, MD 9/11/26 Darrell Wilcox, MD 9/11/26

Does Progesterone Cause Brain Tumors? What the Research Actually Shows

A meningioma headline about progesterone is usually actually about one specific synthetic progestin. Here's what the research shows about which ones carry real risk, and which don't.

Darrell Wilcox, MD 9/7/26 Darrell Wilcox, MD 9/7/26

Your Hair Is Thinning on Hormone Therapy. Testosterone Isn't Always the Reason.

More hair in the shower drain after starting hormone therapy? The dose isn't always the culprit. Here's what's actually driving it, and how to find out.

Darrell Wilcox, MD 9/4/26 Darrell Wilcox, MD 9/4/26

Your Testosterone Isn't Just Declining With Age. It's Declining Across Generations.

In 2017, LabCorp lowered its normal testosterone range for men. That change didn't happen in a vacuum, it responded to a decline researchers had already been tracking for years.

Darrell Wilcox, MD 8/31/26 Darrell Wilcox, MD 8/31/26

Does Estrogen Cause Blood Clots and Strokes? What the Actual Trial Data Shows

Estrogen and blood clot warnings usually skip two details that actually determine the risk: timing after menopause and route of administration. Here's what the randomized trials actually show.

Darrell Wilcox, MD 8/28/26 Darrell Wilcox, MD 8/28/26

Adrenal Fatigue Isn't a Diagnosis. Cellular Cortisol Resistance Is.

Adrenal fatigue is not a standard medical diagnosis. Symptoms can be real even when that label is wrong. Chronic stress can mute how cells hear cortisol while blood levels still look fine.

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